Molecular Mechanisms of Longevity: The Genetics, Genomics, and Cell Biology of Aging

Aging is a fascinating biological phenomenon because it seems inevitable, yet recent research suggests that longevity can be manipulated through genetics and environment. Moreover, aging is the major risk factor for a host of chronic and neurological diseases; thus, understanding the molecular regulation of aging will be critical in addressing these health issues in the future. We will explore the current state of the field, including genetic discoveries of longevity mutants, cell biological and metabolic characterization of aging animals, and genomic and computational analyses used to uncover molecular mechanisms that control longevity.