Biophysical Chemistry I

This course provides a comprehensive introduction to basic principles of macromolecular structure, stability, and interactions. Major topics include protein structure; protein thermodynamics and folding; nucleic acid structure and stability; principles of intermolecular recognition; and principles of ligand-binding analysis. Special emphasis is placed on understanding the relationships between structure and stability; the molecular origins of cooperative effects; and the relationships between covalent and non-covalent properties, in macromolecular systems.